Wegovy vs Saxenda: Which Is Better in 2026?
Comparing Wegovy and Saxenda side by side — weight loss results, side effects, cost, dosing, and who should choose each.
| Category | Wegovy | Saxenda |
|---|---|---|
| Active Ingredient | Semaglutide | Liraglutide |
| Mechanism | GLP-1 receptor agonist | GLP-1 receptor agonist |
| FDA Approved For | Chronic weight management | Chronic weight management |
| Administration | Once weekly injection ✓ | Once daily injection |
| Average Weight Loss | ~16-17% of body weight ✓ | ~8% of body weight |
| Starting Dose | 0.25mg weekly | 0.6mg daily |
| Maximum Dose | 2.4mg weekly | 3mg daily |
| Injections Per Month | 4 ✓ | ~30 |
| Cardiovascular Benefit | Proven — SELECT trial (20% MACE reduction) ✓ | Neutral (LEADER trial was for Victoza) |
| Monthly Cost (US, no insurance) | ~$1,300-1,400 | ~$1,300-1,500 |
| FDA Approval Year | 2021 | 2014 |
| Clinical Trial | STEP series | SCALE series |
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Enzo's Tip
Both are officially in the weight loss game, but Wegovy is the clear upgrade! Double the weight loss, one-seventh the injections — semaglutide just hits different. Saxenda was a trailblazer though, and some patients still swear by it. Enzo salutes the pioneer but has to call it like he sees it: Wegovy is the stronger contender here!
Choose Wegovy if you...
- • Have insurance that covers it
- • Want an established track record
- • Prefer a well-known medication
Choose Saxenda if you...
- • Want maximum weight loss potential
- • Have tried other GLP-1s without success
- • Your doctor recommends it
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Medical Disclaimer: Enzo is a tracking companion, not a doctor. Always consult your healthcare provider before starting, stopping, or changing any medication. The information on this page is for educational purposes only and should not be considered medical advice. Individual results may vary.